Saitama is often seen as an unstoppable force, effortlessly taking down any opponent with a single punch. His overwhelming strength has made many wonder if he could take on an entire organization of monsters without assistance.
The Monster Association is filled with creatures of various strength levels, including some that pose serious threats to other heroes. Unlike one-on-one battles where he finishes opponents instantly, this scenario presents a different challenge—facing a coordinated army of enemies at once.

While his power is unmatched, the question remains whether sheer strength alone is enough to clear out an entire group of highly dangerous foes. Would their numbers and abilities pose any difficulty, or would Saitama eliminate them all with little effort?
Looking at his past battles and the nature of the Monster Association, it is interesting to consider if such a large-scale fight would be any different for him.
Would the Monster Association’s Numbers Make a Difference?
One of the most obvious factors to consider in this battle is the sheer number of enemies. The Monster Association consists of countless creatures, from weaker minions to high-ranking monsters classified as Dragon-level threats.
While most of them are no match for experienced heroes, their ability to attack in large groups could create a rare situation where Saitama faces multiple enemies at once.
Even though his physical capabilities are beyond anything the Monster Association has encountered, a swarm of opponents launching attacks from every direction could at least slow him down. However, based on what has been seen in previous fights, numbers alone do not seem to matter much to Saitama.
His speed and strength allow him to eliminate multiple opponents in an instant, making it unlikely that even a massive group could overwhelm him. If he were to attack aggressively, wiping out large portions of the Monster Association with each strike, the battle could end before they even realize what is happening.
The only way they could stand a chance would be if they had a strategy that went beyond brute force.
Could Any Individual Monster Challenge Him?
While most members of the Monster Association would not last long against him, a few have abilities that could potentially complicate the fight. Orochi, the supposed king of monsters, displayed immense power and adaptability, making him one of the strongest foes introduced.
Psykos, when fused with Orochi, possessed devastating energy-based attacks and large-scale destruction capabilities. Against other heroes, these monsters would have been extremely difficult to defeat, but against someone like Saitama, their chances of survival remain questionable.

For a real challenge to happen, an opponent would need to have abilities that target something beyond physical strength. A monster with the power to manipulate time, space, or reality itself could at least force Saitama to break through something different from the usual physical battles.
However, given his track record, even unconventional powers might not hold him back for long. His ability to defy logic and overpower every enemy he faces suggests that no matter the ability, he would still find a way to win.
Saitama taking on the entire Monster Association alone would likely end the way most of his battles do—with him standing victorious. While their numbers could make the fight last slightly longer than usual, there is little reason to believe that any of them would pose a real threat.
Even the strongest monsters within the organization would struggle to survive a single punch from him. The only way he could face difficulty is if an opponent possessed abilities beyond physical combat, but even then, his past performances suggest that nothing would stop him for long.
Whether fighting one enemy or an entire army, his strength remains an overwhelming force that nothing has been able to counter.